GABAA receptor subtype involvement in addictive behaviour. (20th September 2016)

• Record Type: Journal Article
• Authors: Stephens, D. N.; King, S. L.; Lambert, J. J.; Belelli, D.; Duka, T.
• Is Part Of: Genes, brain, and behavior. Volume 16:Number 1(2017)
• Page Start: 149
• Page End: 184
• Publication Date: 2016-09-20
• Subjects: Alcohol -- animal model -- benzodiazepine -- conduct disorder -- electrophysiology -- gene association -- gene knockout -- impulsivity -- nucleus accumbens -- psychostimulant -- reward; Behavior genetics -- Periodicals; Neurogenetics -- Periodicals; 616.8
• DOI: 10.1111/gbb.12321
• Languages: English
• ISSNs: 1601-1848

Abstract

Abstract : GABAA receptors form the major class of inhibitory neurotransmitter receptors in the mammalian brain. This review sets out to summarize the evidence that variations in genes encoding GABAA receptor isoforms are associated with aspects of addictive behaviour in humans, while animal models of addictive behaviour also implicate certain subtypes of GABAA receptor. In addition to outlining the evidence for the involvement of specific subtypes in addiction, we summarize the particular contributions of these isoforms in control over the functioning of brain circuits, especially the mesolimbic system, and make a first attempt to bring together evidence from several fields to understanding potential involvement of GABAA receptor subtypes in addictive behaviour. While the weight of the published literature is on alcohol dependency, the underlying principles outlined are relevant across a number of different aspects of addictive behaviour. Abstract : GABAA receptors are importantly involved in transmission in brain areas underlying behavioural processes contributing to addictions.