Bacterial Hyaluronidase Self‐Triggered Prodrug Release for Chemo‐Photothermal Synergistic Treatment of Bacterial Infection. Issue 45 (30th September 2016)

• Record Type: Journal Article
• Authors: Ji, Haiwei; Dong, Kai; Yan, Zhengqin; Ding, Chao; Chen, Zhaowei; Ren, Jinsong; Qu, Xiaogang
• Is Part Of: Small. Volume 12:Issue 45(2016)
• Page Start: 6200
• Page End: 6206
• Publication Date: 2016-09-30
• Subjects: antibacterial system -- drug delivery -- hyaluronic acid -- on‐demand -- reactive oxygen species; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201601729
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : A novel platform for targeted on‐demand prodrug ascorbic acid (AA) delivery is fabricated using a bacterial hyaluronidase sensitive graphene‐mesoporous silica nanosheet@hyaluronic acid‐magnetic nanoparticles as the nanocarrier to treat bacterial infections. The released AA can be converted to detrimental OH in situ on the surface of bacteria. With the chemo‐photothermal synergistic effect, the designed antibacterial system can effectively inactivate bacteria and disperse stubborn biofilm.