Clinical trial evaluating the effectiveness of biocompound IMMUNEPOTENT CRP in the third-molar extraction. Issue 1 (2nd January 2017)

• Record Type: Journal Article
• Authors: Franco-Molina, Moises A.; Mendoza-Gamboa, Edgar; Coronado-Cerda, Erika E.; Zarate-Triviño, Diana; Arizpe-Coronado, Juan E.; Zapata-Benavides, Pablo; Ramos Zayas, Yareellys; Tamez-Guerra, Reyes; Rodríguez-Padilla, Cristina
• Is Part Of: Biotechnology, biotechnological equipment. Volume 31:Issue 1(2017)
• Page Start: 182
• Page End: 186
• Publication Date: 2017-01-02
• Subjects: Surgery -- saliva -- inflammation -- cytokine -- IMMUNEPOTENT CRP; Biotechnology -- Periodicals; Biotechnology -- Periodicals; Biotechnology -- instrumentation -- Periodicals; Periodicals; 660.605
• DOI: 10.1080/13102818.2016.1249408
• Languages: English
• ISSNs: 1310-2818

Abstract

ABSTRACT: A controlled, parallel, randomized and comparative trial was carried out to evaluate the anti-inflammatory efficacy of IMMUNEPOTENT CRP versus ibuprofen in patients after third-molar surgery over seven days. The anti-inflammatory efficacy of IMMUNEPOTENT CRP was evaluated using the method of Amin and Laskin, and the analysis of cytokine production (IL-2, IL-4, IL-6, IL-10, TNF-α, INF-γ) in saliva was done by flow cytometry. The swelling process after surgery was significant ( p < 0.05) and the treatments with IMMUNEPOTENT CRP or ibuprofen controlled this process properly; no difference between the groups was found ( p < 0.05). Both treatments were shown to modulate the cytokine production. These results demonstrate the anti-inflammatory activity of the natural compound IMMUNEPOTENT CRP and suggest it could be used in clinical dental practice.