Core–shell alginate@silica microparticles encapsulating probiotics. Issue 48 (24th November 2016)

• Record Type: Journal Article
• Authors: Haffner, F. B.; Girardon, M.; Fontanay, S.; Canilho, N.; Duval, R. E.; Mierzwa, M.; Etienne, M.; Diab, R.; Pasc, A.
• Is Part Of: Journal of materials chemistry. Volume 4:Issue 48(2016)
• Page Start: 7929
• Page End: 7935
• Publication Date: 2016-11-24
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c6tb02802k
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Lactobacillus rhamnosus GG (LGG) was encapsulated in core–shell alginate–silica microcapsules by coating the electrosprayed ionogel with a silica shell via hydrolysis/condensation of alkoxysilane precursors. Abstract : Lactobacillus rhamnosus GG (LGG) was encapsulated in core–shell alginate–silica microcapsules by coating the electrosprayed ionogel with a silica shell via hydrolysis/condensation of alkoxysilane precursors. The viability of encapsulated LGG highly depends on the mineralisation conditions (in aqueous or organic phases), identified as a critical step. More importantly, due to the unswelling of silica and to its mesoporosity that allows nutriment-metabolite diffusion, it was possible to avoid cell leakage and additionally insure bacterial growth inside the microcapsules. The results of this work gave a proof-of-concept for controlled bacterial proliferation in microcompartments, which have straightforward applications in oral delivery of probiotics.