New dinuclear ruthenium arene complexes containing thiosemicarbazone ligands: synthesis, structure and cytotoxic studies. Issue 48 (22nd November 2016)

• Record Type: Journal Article
• Authors: Su, Wei; Tang, Zhaofeng; Li, Peiyuan; Wang, Gufeng; Xiao, Qi; Li, Yuchun; Huang, Shan; Gu, Yunqiong; Lai, Zefeng; Zhang, Yuexing
• Is Part Of: Dalton transactions. Volume 45:Issue 48(2016)
• Page Start: 19329
• Page End: 19340
• Publication Date: 2016-11-22
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c6dt03306g
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : Ruthenium arene complexes incorporating TSC in two types of coordination modes are reported. B-type complexes are the first di-nuclear TSC ruthenium arene complexes with a special four-membered chelate ring. Abstract : A series of mononuclear ruthenium arene complexes with thiosemicarbazone (TSC) ligands (A-type, 1–8 ) and their corresponding di-nuclear analogues (B-type, 9–16 ) were synthesized and characterized by NMR, elemental analysis and HR-ESI-mass spectrometry. The molecular structures of1, 2, 6, 9–11 and13–16 were determined using single-crystal X-ray diffraction analysis. The Gibbs free energy of the two examples of the two types of complexes (1 and9 ) and the bonding order in their single-crystals were studied using density functional theory (DFT) calculations. The compounds were further evaluated for their in vitro antiproliferative activities against CNE-2 human nasopharyngeal carcinoma, KB human oral epithelial carcinoma, SGC-7901 human gastric carcinoma, HepG2 human liver carcinoma, HeLa human cervical carcinoma and HEK-293T noncancerous cell lines. Furthermore, the interactions between the compounds and DNA were studied by electrophoretic mobility spectrometry studies.