16th IHIW: Anti‐HLA alloantibodies of the of IgA isotype in re‐transplant candidates. (22nd December 2012)

• Record Type: Journal Article
• Authors: Arnold, M.‐L.; Heinemann, F. M.; Horn, P.; Ziemann, M.; Lachmann, N.; Mühlbacher, A.; Dick, A.; Ender, A.; Thammanichanond, D.; Fischer, G. F.; Schaub, S.; Hallensleben, M.; Mytilineos, J.; Hitzler, W. E.; Seidl, C.; Doxiadis, I. I. N.; Spriewald, B. M.
• Is Part Of: International journal of immunogenetics. Volume 40:Number 1(2013:Feb.)
• Page Start: 17
• Page End: 20
• Publication Date: 2012-12-22
• Subjects: Immunogenetics -- Periodicals; 571.9648
• DOI: 10.1111/iji.12032
• Languages: English
• ISSNs: 1744-3121

Abstract

Summary: In this multicentre study, sera from 803 retransplant candidates, including 775 kidney transplant recipients, were analysed with regard to the presence and specificity of anti‐HLA alloantibodies of the IgA isotype using a modified microsphere‐based platform. Of the kidney recipients, nearly one‐third ( n = 237, 31%) had IgA alloantibodies. Mostly, these antibodies were found in sera that also harboured IgG alloantibodies that could be found in a total of 572 (74%) of patients. Interestingly, IgA anti‐HLA antibodies were preferentially targeting HLA class I antigens in contrast to those of the IgG isotype, which targeted mostly both HLA class I and II antigens. Donor specificity of the IgA alloantibodies could be established for over half of the 237 patients with IgA alloantibodies ( n = 124, 52%). A further 58 patients had specificities against HLA‐C or HLA‐DP, for which no information regarding donor typing was available. In summary, these data showed in a large cohort of retransplant candidates that IgA alloantibodies occur in about one‐third of patients, about half of these antibodies being donor specific.