Intake of antioxidant vitamins and risk of Parkinson's disease. Issue 12 (27th October 2016)

• Record Type: Journal Article
• Authors: Hughes, Katherine C.; Gao, Xiang; Kim, Iris Y.; Rimm, Eric B.; Wang, Molin; Weisskopf, Marc G.; Schwarzschild, Michael A.; Ascherio, Alberto
• Is Part Of: Movement disorders. Volume 31:Issue 12(2016)
• Page Start: 1909
• Page End: 1914
• Publication Date: 2016-10-27
• Subjects: Parkinson's disease -- vitamin C -- vitamin E -- carotenoids -- oxidative stress; Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.26819
• Languages: English
• ISSNs: 0885-3185

Abstract

ABSTRACT: Introduction: Oxidative stress is proposed to be one of the potential mechanisms leading to neurodegeneration in Parkinson's disease. However, previous epidemiologic studies investigating associations between antioxidant vitamins, such as vitamins E and C and carotenoids, and PD risk have produced inconsistent results. Objective: The objective of this work was to prospectively examine associations between intakes of antioxidant vitamins, including vitamins E and C and carotenoids, and PD risk. Methods: Cases were identified in two large cohorts: the Nurses' Health Study and the Health Professionals Follow‐up Study. Cohort members completed semiquantitative food frequency questionnaires every 4 years. Results: A total of 1036 PD cases were identified. Dietary intakes of vitamin E and carotenoids were not associated with PD risk; the multivariable‐adjusted relative risk comparing extreme intake quintiles were 0.93 (95% confidence interval: 0.75–1.14) and 0.97 (95% confidence interval: 0.69–1.37), respectively. Dietary vitamin C intake was significantly associated with reduced PD risk (relative risk: 0.81; 95% confidence interval: 0.65–1.01; p trend, 0.01); however, this result was not significant in a 4‐year lag analysis. For vitamins E and C, intake from foods and supplements combined were also unrelated to PD risk. Conclusions: Our results do not support the hypothesis that intake of antioxidant vitamins reduces the risk of PD. © 2016 International Parkinson and Movement Disorder Society