Implications of multi wall carbon nanotube over living system using C. elegans as worm model. (2016)

• Record Type: Journal Article
• Authors: Sinha, Swati; Biswas, Kunal; De, Debashis; Bandyopadhyay, Jaya
• Is Part Of: Materials today. Volume 3(2016) Part A
• Page Start: 3310
• Page End: 3317
• Publication Date: 2016
• Subjects: MWCNT -- Caenorhabditis elegans -- Toxicity -- Survival assay -- Motility -- Biocompatibility; Materials science -- Congresses -- Periodicals; 620.1
• DOI: 10.1016/j.matpr.2016.10.012
• Languages: English
• ISSNs: 2214-7853

Abstract

Abstract: Multi-walled carbon-nanotubes are considered as promising drug-delivery tool for their unique physicochemical properties. The aim of our study is to assess the biological impact of pristine MWCNT in an in vivo model using Caenorhabditis elegans since it shares 60-80% homologous genes with human genome. The toxicity of MWCNT was determined by evaluating survival assay and motility of C. elegans . Gradual increase in the concentration of pristine MWCNT imparted adverse effects on survival potential and motility of C. elegans gradually. Death rate of worms increased from 7%-17% after 24 hours and from14%-23% after 48 hours with increasing concentrations of MWCNT treatment.