An updated structural classification of substrate‐binding proteins. Issue 23 (23rd October 2016)

• Record Type: Journal Article
• Authors: Scheepers, Giel H.; Lycklama a Nijeholt, Jelger A.; Poolman, Bert
• Is Part Of: FEBS letters. Volume 590:Issue 23(2016)
• Page Start: 4393
• Page End: 4401
• Publication Date: 2016-10-23
• Subjects: ABC transporter -- membrane protein -- signal transduction -- solute transport -- structural classification -- substrate‐binding protein; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.12445
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Substrate‐binding proteins (SBPs) play an important role in solute uptake and signal transduction. In 2010, Berntsson et al . classified the 114 organism‐specific SBP structures available at that time and defined six protein clusters, based on their structural similarity. Since then, the number of unique SBP structures has increased almost fivefold, whereas the number of protein entries in the Protein Data Bank (PDB) nearly doubled. On the basis of the much larger dataset, we now subclassify the SBPs within the original clusters. Moreover, we propose a 7th cluster based on a small group of SBPs with structural features significantly different from those observed in the other proteins. Abstract :