Lineariifolianoids I–L, four rare sesquiterpene lactone dimers inhibiting NO production from Inula lineariifolia. Issue 105 (31st October 2016)

• Record Type: Journal Article
• Authors: Chen, Li-Ping; Wu, Guo-Zhen; Dong, Hong-Yuan; Yang, Niao; Zhang, Wei-Dong; Li, Hui-Liang
• Is Part Of: RSC advances. Volume 6:Issue 105(2016)
• Page Start: 103296
• Page End: 103298
• Publication Date: 2016-10-31
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra23092j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Four unsymmetrical sesquiterpene lactone dimers were isolated from Inula lineariifolia . The absolute configurations of1 and2 were established by X-ray crystallographic analyses. Abstract : A rare 4, 5- seco -pseudoguaiane–guaiane type sesquiterpene lactone dimer lineariifolianoid I (1 ), together with three xanthane–guaiane type dimers lineariifolianoids J–L (2–4 ) were isolated from Inula lineariifolia . Their structures and absolute configurations were established on the basis of spectroscopic data and X-ray crystallography. Compounds1 and2 exhibited significant inhibitory activity against LPS-induced NO production in RAW 264.7 macrophages with IC50 values of 1.02, 1.79 μM.