The role of fluids in high-pressure polymorphism of drugs: different behaviour of β-chlorpropamide in different inert gas and liquid media. Issue 95 (28th September 2016)

• Record Type: Journal Article
• Authors: Zakharov, B. A.; Seryotkin, Y. V.; Tumanov, N. A.; Paliwoda, D.; Hanfland, M.; Kurnosov, A. V.; Boldyreva, E. V.
• Is Part Of: RSC advances. Volume 6:Issue 95(2016)
• Page Start: 92629
• Page End: 92637
• Publication Date: 2016-09-28
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra17750f
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Compression of β-chlorpropamide gives different phases depending on the choice of non-dissolving pressure-transmitting fluid (paraffin, neon and helium). Abstract : The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1 : 1 pentane–isopentane mixture.