Ru-catalyzed direct amidation of carboxylic acids with N-substituted formamides. Issue 50 (15th December 2016)

• Record Type: Journal Article
• Authors: Bi, Xiaojing; Li, Junchen; Shi, Enxue; Wang, Hongmei; Gao, Runli; Xiao, Junhua
• Is Part Of: Tetrahedron. Volume 72:Issue 50(2016)
• Page Start: 8210
• Page End: 8214
• Publication Date: 2016-12-15
• Subjects: Amide -- Carboxylic acids -- N-substituted formamides -- Ru-catalyzed; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2016.10.043
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: The direct amidation of carboxylic acids with N -substituted formamides has been accomplished via ruthenium catalysis. In the presence of ruthenium catalyst, a versatile range of carboxylic acids and N -substituted formamides undergoes amidation reaction to produce synthetically useful amides in good yields. CO in amide product came from benzoic acid but not N -substituted formamides, and which was confirmed by Isotope experiment. Graphical abstract: The direct amidation of carboxylic acids with N -substituted formamides has been accomplished via ruthenium catalysis. A versatile range of carboxylic acids and N -substituted formamides undergoes amidation reaction to produce synthetically useful amides in good yields. CO in amide product came from benzoic acid but not N-substituted formamides, and which was confirmed by Isotope experiment.