Detecting autonomic response to pain in Rett syndrome. (17th February 2017)

• Record Type: Journal Article
• Authors: O'Leary, Heather M.; Marschik, Peter B.; Khwaja, Omar S.; Ho, Eugenia; Barnes, Katherine V.; Clarkson, Tessa W.; Bruck, Natalie M.; Kaufmann, Walter E.
• Is Part Of: Developmental neurorehabilitation. Volume 20:Number 2(2017)
• Page Start: 108
• Page End: 114
• Publication Date: 2017-02-17
• Subjects: Electrodermal activity -- FLACC -- heart rate -- pain -- Rett syndrome -- skin conductance; Children with disabilities -- Rehabilitation -- Periodicals; Developmentally disabled children -- Rehabilitation -- Periodicals; 615.542
• DOI: 10.3109/17518423.2015.1087437
• Languages: English
• ISSNs: 1751-8423

Abstract

Abstract: Objective : To quantify pain response in girls affected by Rett syndrome (RTT) using electrodermal activity (EDA), a measure of skin conductance, reflecting sympathetic activity known to be modulated by physical and environmental stress. Methods : EDA increase, heart rate (HR) increase and Face Legs Activity Cry Consolability (FLACC) values calculated during venipuncture (invasive) and vital signs collection (non-invasive) events were compared with values calculated during a prior baseline and a RTT clinical severity score (CSS). Results : EDA and HR increase were significantly higher than baseline during venipuncture only and not significantly correlated with FLACC or CSS. EDA increase was the most sensitive measure of pain response. Conclusions : These preliminary findings revealed that motor impairment might bias non-verbal pain scales, underscore the importance of using autonomic measures when assessing pain and warrant further investigation into the utility of using EDA to objectively quantify RTT pain response to inform future RTT pain management.