Claes Hellerström and Cartesian diver microrespirometry. (2nd April 2016)

• Record Type: Journal Article
• Authors: Welsh, Michael
• Is Part Of: Upsala journal of medical sciences. Volume 121:Number 2(2016)
• Page Start: 77
• Page End: 80
• Publication Date: 2016-04-02
• Subjects: Cartesian diver -- glucose -- insulin secretion -- islets of Langerhans -- respiration; Medicine -- Periodicals; Medicine -- Periodicals; Electronic journals; 610.5
• DOI: 10.3109/03009734.2015.1109012
• Languages: English
• ISSNs: 0300-9734

Abstract

Abstract: Cartesian diver microrespirometry was introduced by Claes Hellerström at the Department of Histology/Medical Cell Biology at Uppsala University, Sweden, to determine rates of oxygen consumption in islets of Langerhans. The theory behind this method is touched upon and the main findings described. Glucose-stimulated beta cell respiration significantly contributes to increased ATP generation, which is a prerequisite for stimulated insulin secretion and synthesis. This has had major implications for understanding the beta cell stimulus–secretion coupling.