Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and head and neck cancers risk. (January 2017)

• Record Type: Journal Article
• Authors: Bravi, Francesca; Polesel, Jerry; Garavello, Werner; Serraino, Diego; Negri, Eva; Franchin, Gianni; La Vecchia, Carlo; Bosetti, Cristina
• Is Part Of: Oral oncology. Volume 64(2017)
• Page Start: 59
• Page End: 64
• Publication Date: 2017-01
• Subjects: AICR American Institute for Cancer Research -- BMI body mass index -- CI confidence interval -- EPIC European Prospective Investigation into Nutrition and Cancer -- FFQ food frequency questionnaire -- INHANCE International Head and Neck Cancer Epidemiology -- OCP oral cavity and pharyngeal -- OR odds ratios -- WCRF World Cancer Research Fund; American Institute for Cancer Research -- Diet -- Head and neck cancer -- Risk factors -- World Cancer Research Fund -- Case control study; Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2016.11.012
• Languages: English
• ISSNs: 1368-8375

Abstract

Abstract: Objectives: The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) have proposed eight recommendations for cancer prevention, related to body fatness, diet, and physical activity. Our aim is to evaluate the role of adherence to these recommendations on head and neck cancers risk. Materials and methods: We obtained an overall score including seven of the WCRF/AICR recommendations, and examined its relationship with head and neck cancers risk in two Italian case-control studies including 946 patients with oral cavity and pharyngeal (OCP) cancer and 2492 controls, and 689 patients with laryngeal cancer and 1605 controls. Results: Higher adherence to WCRF/AICR recommendations was associated to a reduced risk of OCP cancer (odds ratio, OR = 0.45, 95% confidence interval, CI: 0.33–0.62 for a score of 4–<5, and OR = 0.32, 95% CI: 0.22–0.49 for a score of ⩾5 as compared to <3). The ORs for laryngeal cancer were 0.68 (95% CI: 0.50–0.92) for a score of 3–<4, 0.39 (95% CI: 0.28–0.55) for a score of 4–<5, and 0.24 (95% CI: 0.15–0.38) for a score of ⩾5. Conclusion: Our study indicates that high adherence to the WCRF/AICR recommendations for cancer prevention is associated with a substantially decreased risk of head and neck cancers.