Use of potential dietary phytochemicals to target miRNA: Promising option for breast cancer prevention and treatment?. (January 2017)

• Record Type: Journal Article
• Authors: Sayeed, Md. Abu; Bracci, Massimo; Lazzarini, Raffaella; Tomasetti, Marco; Amati, Monica; Lucarini, Guendalina; Di Primio, Roberto; Santarelli, Lory
• Is Part Of: Journal of functional foods. Volume 28(2017)
• Page Start: 177
• Page End: 193
• Publication Date: 2017-01
• Subjects: ALDH1 aldehyde dehydrogenase 1 -- AKT protein kinase B -- ARID4B AT-rich interactive domain-containing protein 4B -- BMI1 B-lymphoma Moloney murine leukemia virus insertion region-1 -- BMP1 bone morphogenetic protein 1 -- BRCA1 breast cancer 1 -- BIRC6 baculoviral IAP repeat-containing protein 6 -- CDC42 cell division cycle 42 -- CXCR4 C-X-C chemokine receptor type 4 -- CD1/24/44/49f cluster of differentiation 1/24/44/49f -- CRIP2 cysteine-rich protein 2 -- DNAJB6 DnaJ homolog subfamily B member 6 -- ER-α estrogen receptor-α -- EGFR epidermal growth factor receptor -- Fra-1 Fos-related antigen 1 -- FOXO1/O3a/Q1 forkhead box O1/O3a/Q1 -- HER2 human epidermal growth factor receptor 2 -- HOXD10 homeobox D10 -- HMGA2 high-mobility group AT-hook 2 -- IGFBP2/5 insulin-like growth factor-binding protein 2/5 -- ITGB3 integrin subunit beta 3 -- Klf4 Kruppel-like factor 4 -- Myt-1 myelin transcription factor 1 -- MIM missing in metastasis -- MERTK proto-oncogene tyrosine-protein kinase MER -- MTDH metadherin -- NRP1 neuropilin-1 -- PI3K phosphatidylinositide 3-kinase -- PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -- PDCD4 programmed cell death protein 4 -- pMDM2 phospho mouse double minute 2 homolog -- PTEN phosphatase and tensin homolog -- RECK reversion-inducing-cysteine-rich protein with kazal motifs -- SOX4/9 SRY-related HMG-box 4/9 -- RASD1 Ras related dexamethasone induced 1 -- Smad2 mothers against decapentaplegic homolog 2 -- SIP1 Smad interacting protein 1 -- TPA 12-O-tetradecanoylphorbol-13-acetate -- TGF-β transforming growth factor beta -- TET ten-eleven-translocation -- TNC tenascin C -- TIMP1/3 metallopeptidase inhibitor 1/3 -- Ubc9 ubiquitin conjugating 9 -- ZEB1/2 zinc finger E-box-binding homeobox 1/2 -- ZBTB4/10/34 zinc finger and BTB domain containing 4/10/34; Dietary phytochemicals -- miRNA -- Breast cancer -- In vitro -- In vivo; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2016.11.008
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Effects of some dietary phytochemicals on breast cancer miRNAs are discussed. Dietary phytochemicals may inhibit breast cancer by regulating miRNAs expression. In vivo studies and clinical trials are needed. Some potential dietary phytochemicals still remain to be tested. A large number of miRNAs still remain to be considered. Abstract: Breast cancer is one of the most common forms of cancers in females. Traditional therapies are associated with adverse side effects, and drug resistance, recurrence, and lack of treatment in metastasis are the major problems. Accumulating evidence indicates that dietary phytochemicals may exert therapeutic effects by regulating miRNA expression. A number of dietary phytochemicals have been tested as miRNA regulatory agents against breast cancer, and some other numbers of dietary phytochemicals have not yet been tested. Our aim is to introduce some of the potential dietary phytochemicals (benzyl isothiocyanate, capsaicin, epigallocatechin gallate, oleanolic acid, phenethyl isothiocyanate, and ursolic acid) that have shown miRNA regulatory activities, and have not yet been tested against breast cancer miRNAs. We also discuss the effects of curcumin, diallyl disulphide, 3, 3′-diindolylmethane, ellagic acid, genistein, indole-3-carbinol, quercetin, resveratrol, and sulforaphane on regulation of expression of breast cancer miRNAs in various in vitro and in vivo models.