Photo‐induced graft‐versus‐host disease. Issue 5 (19th October 2016)

• Record Type: Journal Article
• Authors: Hardy, Juliette M.; Marguery, Marie‐Claude; Huynh, Anne; Borel, Cécile; Apoil, Pol André; Lamant, Laurence; Tournier, Emilie; Alberto, Chloé; Pauwels, Céline; Thomas, Marianne; Mazereeuw Hautier, Juliette; Paul, Carle; Bulai Livideanu, Cristina
• Is Part Of: Photodermatology, photoimmunology & photomedicine. Volume 32:Issue 5/6(2016)
• Page Start: 291
• Page End: 295
• Publication Date: 2016-10-19
• Subjects: overlap chronic GVH disease -- photodermatosis -- ultraviolet B -- ultraviolet radiation; Photosensitivity disorders -- Periodicals; Dermatology -- Periodicals; Immunology -- Periodicals; 616.5
• DOI: 10.1111/phpp.12273
• Languages: English
• ISSNs: 0905-4383

Abstract

Summary: Overlap chronic graft‐versus‐host disease (GVHD) associates both features of acute and chronic GVHD. Trigger factors for chronic GVHD are unclear. We describe two patients who received allogenic haematopoietic stem‐cell transplantation, and who later developed overlap chronic GVHD after sun exposure. Available data from in vivo investigations suggest ultraviolet B radiation (UVB) has a beneficial effect on acute and chronic GVHD. The role of sun irradiation as a trigger for isomorphic cutaneous GVHD has been rarely reported in the literature. Herein, we demonstrate for the first time, using repetitive broadband phototesting, that UVB triggers chronic GVHD.