Atonic elements combined or uncombined with epileptic spasms in infantile spasms. Issue 1 (January 2017)

• Record Type: Journal Article
• Authors: Xue, Jiao; Qian, Ping; Li, Hui; Yang, Haipo; Liu, Xiaoyan; Zhang, Yuehua; Yang, Zhixian
• Is Part Of: Clinical neurophysiology. Volume 128:Issue 1(2017:Jan.)
• Page Start: 220
• Page End: 226
• Publication Date: 2017-01
• Subjects: ACTH adrenocorticotropic hormone -- AEDs antiepileptic drugs -- ILAE International League Against Epilepsy -- MRI magnetic resonance imaging -- PEMG polyelectromyography -- VEEG video-electroencephalogram; Atonic seizures -- Epileptic spasms -- Infantile spasms; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2016.11.008
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Atonia combined or uncombined with spasms was an ignored phenomenon in infantile spasms. Atonic elements combined or uncombined with spasms were artificially divided into three subtypes. Atonic elements in infantile spasms might be a variant of epileptic spasms or a new seizure type. Abstract: Objective: To study the atonic elements combined or uncombined with epileptic spasms in infantile spasms. Methods: The demographic data, clinical characteristics, electroencephalogram (EEG), and polyelectromyography (PEMG) features were analyzed in 12 infantile spasm patients with atonic elements. Results: A total of 29 EEGs were recorded. Hypsarrhythmia or hypsarrhythmia variants were identified during interictal EEG. Insular or clustered epileptic spasms occurred in all. Three subtypes of atonic elements combined or uncombined with epileptic spasms (spasm-atonic, pure atonic, and atonic-spasm seizures) were observed electroclinically, which could present insularly or in cluster or altered with epileptic spasms in the same cluster. The ictal EEG showed generalized high-amplitude slow waves presenting alone or combined with other patterns. The corresponding PEMG showed an obvious electrical silence alone or preceding or following a crescendo-decrescendo pattern generated from myoelectric burst. Conclusions: Atonic elements combined or uncombined with epileptic spasms was a newly noticed phenomenon in infantile spasms, which was artificially divided into three subtypes here. It might be a variant of epileptic spasms or a unique seizure type. Significance: Atonic elements combined or uncombined with epileptic spasms was a previously ignored phenomenon in infantile spasms, which should be seriously considered in clinical practice.