Hepatocellular carcinoma: Mouse models and the potential roles of proteases. (28th February 2017)

• Record Type: Journal Article
• Authors: Henderson, James M.; Zhang, Hui Emma; Polak, Natasa; Gorrell, Mark D.
• Is Part Of: Cancer letters. Volume 387(2017)
• Page Start: 106
• Page End: 113
• Publication Date: 2017-02-28
• Subjects: Hepatocellular carcinoma -- Dipeptidyl peptidase -- Mouse models -- Fibroblast activation protein; CAF cancer associated fibroblasts -- DEN diethylnitrosamine -- DPP dipeptidyl peptidase -- ECM extracellular matrix -- EGF epidermal growth factor -- EMT epithelial–mesenchymal transition -- FAP fibroblast activation protein -- FGF fibroblast growth factor -- HCC hepatocellular carcinoma -- HFD high fat diet -- HSC hepatic stellate cells -- MMP matrix metalloproteinase -- NMDA N-nitrosodiethylamine -- PB phenobarbital -- TAA thioacetamide -- TAM tumour associated macrophages; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2016.03.047
• Languages: English
• ISSNs: 0304-3835

Abstract

Highlights: A range of liver cell types influence the tumour microenvironment. Proteases, particularly post-proline peptidases, are important in tumour growth. Chemically induced liver cancer models are influenced by strain, gender and timing. The timing of diethylnitrosamine administration for liver cancer induction is discussed. Abstract: Primary liver cancer is the second most common cause of mortality from cancer. The most common models of hepatocellular carcinoma, which use a chemical and/or metabolic insult, xenograft, or genetic manipulation, are discussed in this review. In the tumour microenvironment lymphocytes, fibroblasts, endothelial cells and antigen presenting cells are important determinants of cell fate. These cells make a range of proteases that modify the biological activity of other proteins, particularly extracellular matrix proteins that alter cell migration of tumour cells, fibroblasts and leucocytes, and chemokines that alter leucocyte migration. The DPP4 family of post-proline peptidase enzymes modifies cell movement and the activities of many bioactive molecules including growth factors and chemokines.