Investigation of CD40 gene rs4810485 and rs1883832 mutations in patients with recurrent aphthous stomatitis. (February 2017)

• Record Type: Journal Article
• Authors: Yigit, Serbulent; Tekcan, Akin; Rustemoglu, Aydin; Tumer, Mehmet Kemal; Kalkan, Goknur; Yerliyurt, Kaan
• Is Part Of: Archives of oral biology. Volume 74(2017)
• Page Start: 51
• Page End: 54
• Publication Date: 2017-02
• Subjects: CD40 gene -- RAS -- Mutations; Mouth -- Periodicals; Mouth -- Diseases -- Periodicals; Dentistry -- Periodicals; Electronic journals; 617.6005
• DOI: 10.1016/j.archoralbio.2016.11.003
• Languages: English
• ISSNs: 0003-9969

Abstract

Highlights: The results of this study suggest that CD40 gene rs4810485 and rs1883832 mutations were not predisposition to develop RAS in Turkish population. Our findings provide additional information about whether the role of CD40 for RAS development. The present study is pioneer study investigate associations between RAS and CD40 gene mutations. Abstract: Objectives: Recurrent aphthous stomatitis (RAS) is a common painful disorder affecting oral health, mucosa and overall quality of life. The etiopathogenesis of RAS remains unclear. RAS shows a large genetic diversity among the patients. In present study, we investigated whether CD40 gene rs4810485 and rs1883832 are associated with RAS and its clinical findings in Turkish patients. Materials and methods: Genomic DNA obtained from 387 individuals (160 patients with RAS and 227 healthy controls) were used in the study. CD40 gene rs4810485 and rs1883832 mutations were determined by using polymerase chain reaction with the specific primers. Results: There was no statistically significant difference between the groups with respect to genotype and allele distribution (p > 0.05, OR 0.94, 95% CI 0.70–1.28, OR 1.01 95% CI 0.75–1.37, respectively). Additionally, there was no statistically significant difference in the combined genotype analysis of CD40 gene rs4810485 and rs1883832 mutations (p > 0.05). Conclusions: According to our results, we found that CD40 gene mutations are not associated with RAS. We are convinced that CD40 gene mutations do not predispose to develop RAS in Turkish population. To our knowledge, this is the first study regarding CD40 gene rs4810485 and rs1883832 mutations investigated in RAS patients.