Model‐free functional connectivity and impulsivity correlates of alcohol dependence: a resting‐state study. (3rd June 2015)

• Record Type: Journal Article
• Authors: Zhu, Xi; Cortes, Carlos R.; Mathur, Karan; Tomasi, Dardo; Momenan, Reza
• Is Part Of: Addiction biology. Volume 22:Number 1(2017)
• Page Start: 206
• Page End: 217
• Publication Date: 2015-06-03
• Subjects: Alcohol dependence -- fMRI -- functional connectivity -- ICA -- impulsivity -- resting state; Substance abuse -- Periodicals; Substance abuse -- Physiological aspects -- Periodicals; Substance-Related Disorders -- periodicals; 616.86
• DOI: 10.1111/adb.12272
• Languages: English
• ISSNs: 1355-6215

Abstract

Abstract: Alcohol dependence is characterized by impulsiveness toward consumption despite negative consequences. Although neuro‐imaging studies have implicated some regions underlying this disorder, there is little information regarding its large‐scale connectivity pattern. This study investigated the within‐ and between‐network functional connectivity (FC) in alcohol dependence and examined its relationship with clinical impulsivity measures. Using probabilistic independent component analysis on resting‐state functional magnetic resonance imaging (rs‐fMRI) data from 25 alcohol‐dependent (AD) and 26 healthy control (HC) participants, we compared the within‐ and between‐network FC between AD and HC. Then, the relationship between FC and impulsiveness as measured by the Barratt Impulsiveness Scale (BIS‐11), the UPPS‐P Impulsive Scale and the delay discounting task (DDT), was explored. Compared with HC, AD exhibited increased within‐network FC in salience (SN), default mode (DMN), orbitofrontal cortex (OFCN), left executive control (LECN) and amygdala–striatum (ASN) networks. Increased between‐network FC was found among LECN, ASN and SN. Between‐network FC correlations were significantly negative between Negative‐Urgency and OFCN pairs with right executive control network (RECN), anterior DMN (a‐DMN) and posterior DMN (p‐DMN) in AD. DDT was significantly correlated with the between‐network FC among the LECN, a‐DMN and SN in AD. These findings add evidence to the concept of altered within‐network FC and also highlight the role of between‐network FC in the pathophysiology of AD. Additionally, this study suggests differential neurobiological bases for different clinical measures of impulsivity that may be used as a systems‐level biomarker for alcohol dependence severity and treatment efficacy. Abstract : We investigated the resting state functional connectivity (FC) in alcohol dependent patients (ADs) and examined its relationship with clinical impulsivity measures. ADs exhibited increased within‐network FC in salience (SN), default‐mode (DMN), orbitofrontal cortex (OFCN), left executive control (LECN) and amygdala‐striatum (ASN) networks. Increased between‐network FC was found among LECN, ASN and SN. Between‐network FC correlations with impulsivity measures were also found in ADs. These findings add evidence to the concept of altered FC in the pathophysiology of ADs.