Bioactive secondary metabolites with multiple activities from a fungal endophyte. Issue 1 (19th December 2016)

• Record Type: Journal Article
• Authors: Bogner, Catherine W.; Kamdem, Ramsay S.T.; Sichtermann, Gisela; Matthäus, Christian; Hölscher, Dirk; Popp, Jürgen; Proksch, Peter; Grundler, Florian M.W.; Schouten, Alexander
• Is Part Of: Microbial biotechnology. Volume 10:Issue 1(2017:Jan.)
• Page Start: 175
• Page End: 188
• Publication Date: 2016-12-19
• Subjects: Microbial biotechnology -- Periodicals; Biotechnology; Microbiology; 660.62
• DOI: 10.1111/1751-7915.12467
• Languages: English
• ISSNs: 1751-7915

Abstract

Summary: In order to replace particularly biohazardous nematocides, there is a strong drive to finding natural product‐based alternatives with the aim of containing nematode pests in agriculture. The metabolites produced by the fungal endophyte Fusarium oxysporum 162 when cultivated on rice media were isolated and their structures elucidated. Eleven compounds were obtained, of which six were isolated from a Fusarium spp. for the first time. The three most potent nematode‐antagonistic compounds, 4‐hydroxybenzoic acid, indole‐3‐acetic acid (IAA) and gibepyrone D had LC50 values of 104, 117 and 134 μg ml −1, respectively, after 72 h. IAA is a well‐known phytohormone that plays a role in triggering plant resistance, thus suggesting a dual activity, either directly, by killing or compromising nematodes, or indirectly, by inducing defence mechanisms against pathogens (nematodes) in plants. Such compounds may serve as important leads in the development of novel, environmental friendly, nematocides. Abstract : GA text‐Biochemical and biological analysis of constituents produced by an endophyte can lead to the discovery of individual compounds with a dual protective role in plant‐pathogen interactions, i.e., directly, by intoxicating a plant pathogen on the one hand and, indirectly, by inducing an increase in plant vigor and triggering plant defenses against a pathogen on the other. This supports the discovery of new nematocides that are environmentally more sound and, from the perspective of resistance development, potentially more robust than those that are currently available on the market.