An ERP Study of Response Inhibition in the Auditory Domain in Children with Fetal Alcohol Spectrum Disorders. (7th December 2016)

• Record Type: Journal Article
• Authors: Gerhold, Matthew M.; Jacobson, Sandra W.; Jacobson, Joseph L.; Molteno, Christopher D.; Meintjes, Ernesta M.; Andrew, Colin M.
• Is Part Of: Alcoholism. Volume 41:Number 1(2017)
• Page Start: 96
• Page End: 106
• Publication Date: 2016-12-07
• Subjects: Event‐Related Potentials -- Response Inhibition -- Fetal Alcohol Syndrome -- Fetal Alcohol Spectrum Disorders -- Prenatal Alcohol Exposure -- Go/NoGo; Alcoholism -- Periodicals; Alcoholism -- Periodicals; Alcoolisme; Electronic journals; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.861005
• DOI: 10.1111/acer.13263
• Languages: English
• ISSNs: 0145-6008

Abstract

Abstract : Background: Previous event‐related potential (ERP) studies of response inhibition in children with fetal alcohol spectrum disorder (FASD) have used a visual Go/NoGo task to study the impact of prenatal alcohol exposure on response inhibition. No studies exist using auditory versions of the task; thus, it is unclear how the deficits observed in visual tasks translate into the auditory domain. Methods: This study examined ERPs using an auditory Go/NoGo paradigm in a sample of 35 school‐age children—18 with heavy prenatal alcohol exposure and 17 normally developing controls. Results: Alcohol‐exposed children performed as well as controls in terms of inhibiting their responses; however, their reaction times were significantly slower under the Go condition. As in the ERP visual Go/NoGo task previously administered to these children, group differences were seen in early perceptual processing, specifically related to stimulus discrimination, with a decrease in P2 amplitude in the alcohol‐exposed group. The control group exhibited greater N2 amplitude in the NoGo compared to the Go condition while the alcohol‐exposed group did not, suggesting a group difference in the neural substrates underlying conflict monitoring. The alcohol‐exposed group demonstrated longer latency P3 with reduced amplitude, suggesting poorer allocation of attention. The alcohol‐exposed group also exhibited a late positive component (LPC) similar to the one observed in the previous visual ERP study. This LPC may indicate compensatory neurophysiological function related to resetting of attentional control networks in preparation for the next trial. None of the ERP outcomes in this study were related to potential confounders which included cognitive and socioeconomic measures as well as ADHD diagnosis. Conclusions: The observed ERP group differences point to elements of perceptual and attentional processing likely to be involved in the performance deficits often observed in children with FASD. We also observed changes in ERPs related to conflict monitoring/response inhibition, highlighting fetal alcohol‐related effects on how the brain responds when there is need to identify and respond to environmental cues by switching away from a prepotent motor response to an inhibited state. Abstract : Our ERP study demonstrated prenatal alcohol effects on an auditory Go/NoGo task requiring switching away from a prepotent motor response. Although alcohol‐exposed children performed behaviorally as well as controls, their decreased P2 amplitude suggested poorer stimulus discrimination; greater N2 amplitude in the NoGo compared to the Go condition suggested an effect on the neural substrates mediating conflict monitoring; and longer latency P3 with reduced amplitude suggested poorer allocation of attention. These effects were not attributable to lower IQ or comorbid ADHD.