A class of sulfonamides as carbonic anhydrase I and II inhibitors. (2nd November 2016)

• Record Type: Journal Article
• Authors: Gokcen, Taner; Gulcin, Ilhami; Ozturk, Turan; Goren, Ahmet C.
• Is Part Of: Journal of enzyme inhibition and medicinal chemistry. Volume 31(2016:Apr.)Supplement 2
• Page Start: 180
• Page End: 188
• Publication Date: 2016-11-02
• Subjects: Enzyme inhibition -- gallic acid -- p-hydroxybenzoic acid; Enzyme inhibitors -- Periodicals; Enzyme Inhibitors -- periodicals; Biochemistry -- periodicals; 572.7
• DOI: 10.1080/14756366.2016.1198900
• Languages: English
• ISSNs: 1475-6366

Abstract

Abstract: Four groups of novel sulfonamide derivatives: (i) acetoxybenzamide, (ii) triacetoxybenzamide, (iii) hydroxybenzamide and (iv) trihydroxybenzamide, all having thiazole, pyrimidine, pyridine, isoxazole and thiadiazole moieties were prepared and their inhibitory effects were studied on two metalloenzymes, i.e. carbonic anhydrase isozymes (hCA I and II), purified from human erythrocyte cells by Sepharose-4B-l -tyrosine-sulfanilamide affinity chromatography. These enzymes are present in almost all living organisms to catalyse the synthesis of bicarbonate ion (HCO3 − ) from carbon dioxide and water. The sulfonamide derivatives were found to be active against hCA I and II in the range of 2.62–136.54 and 5.74–210.58 nM, respectively.