Thermosensitive magnetic liposomes with doxorubicin cell-penetrating peptides conjugate for enhanced and targeted cancer therapy. (21st November 2016)

• Record Type: Journal Article
• Authors: Lin, Wen; Xie, Xiangyang; Yang, Yanfang; Fu, Xudong; Liu, Hong; Yang, Yang; Deng, Jianping
• Is Part Of: Drug delivery. Volume 23:Number 9(2016:Dec.)
• Page Start: 3436
• Page End: 3443
• Publication Date: 2016-11-21
• Subjects: Cell-penetrating peptides -- durg delivery -- liposomes -- magnetic guidance -- thermosensitive release; Drug delivery systems -- Periodicals; Drug targeting -- Periodicals; 615.05
• DOI: 10.1080/10717544.2016.1189983
• Languages: English
• ISSNs: 1071-7544

Abstract

Abstract: To specifically deliver cytotoxic drug to tumor cells and enhance cellular uptake is the key for effective cancer therapy. In this paper, we described a novel drug targeting system, which is designed to combine features of biological (cell-penetrating peptides, CPPs) and physical (magnetic) drug targeting for use in the magnetic hyperthermia-triggered release. A doxorubicin–CPPs conjugate (DOX-CPPs) was loaded into thermosensitive magnetic liposomes (TSMLs) (DOX-CPPs/TSMLs), and in vitro DOX-CPPs thermosensitive release activity, anti-proliferation effect, in vivo targeted delivery as well as in vivo antitumor activity were determined. The results demonstrated that the DOX-CPPs/TSMLs showed good physicochemical properties, effective anti-proliferation effect in MCF-7 cells in vitro . Additionally, in vivo study, DOX-CPPs/TSMLs under AC magnetic field displayed superior in vivo targeted delivery efficacy, antitumor efficacy in an MCF-7 xenograft murine model. In conclusion, the application of DOX-CPPs/TSMLs under AC magnetic field may provide a strategy for the selective and efficient delivery of drug.