Validity of the Portuguese CHO‐KLAT in Brazil. (25th July 2016)

• Record Type: Journal Article
• Authors: Villaça, P. R.; Blanchette, V. S.; Carneiro, J. D. A.; Ozelo, M. C.; Antunes, S.; Feldman, B. M.; Abad, A.; Usuba, K.; Young, N. L.
• Is Part Of: Haemophilia. Volume 22:Number 6(2016:Nov.)
• Page Start: 894
• Page End: 897
• Publication Date: 2016-07-25
• Subjects: haemophilia -- outcome measurement -- paediatrics -- quality of life; Hemophilia -- Periodicals; 616.1572005
• DOI: 10.1111/hae.13031
• Languages: English
• ISSNs: 1351-8216

Abstract

Abstract : Introduction: It is essential to assess the health‐related quality of life outcomes of boys with haemophilia in Brazil. The Canadian Haemophilia Outcomes‐Kids Life Assessment Tool (CHO‐KLAT) was recently adapted for this population. Aim: To test the construct validity of the Portuguese version of the CHO‐KLAT. Methods: We recruited 50 boys, with moderate [factor VIII (FVIII) level 1–5%] or severe (FVIII level <1%) haemophilia, to participate in a descriptive study to establish a baseline understanding of the current status of boys with haemophilia in Brazil. All boys were required to complete the Brazilian CHO‐KLAT and Brazilian Pediatric Quality of Life Inventory (PedsQL) by self‐report. We examined the correlation between the CHO‐KLAT and PedsQL scores to establish the construct validity of the Brazilian version of the CHO‐KLAT. Results: We obtained CHO‐KLAT and PedsQL data from 35 boys with severe haemophilia and 15 with moderate haemophilia. They ranged in age from 7.3 to 18.0 years, with a mean of 13.0 years. They reported a mean CHO‐KLAT score of 72.3 (range = 44.1–93.9). The mean PedsQL score was 79.9 (range = 45.7–96.7), with physical health (mean of 83.9) being better than psychosocial health (77.8). The Pearson's correlation between CHO‐KLAT and PedsQL was 0.47 respectively ( P < 0.001). The CHO‐KLAT had a moderate and inverse relationship with the degree to which they were bothered by their haemophilia (ρ = −0.53), while the PedsQL had a weaker relationship (ρ = −0.27). Conclusion: The results confirm the validity of the Portuguese version of the CHO‐KLAT. This measure is now available for clinical trials in boys with haemophilia in Brazil.