The potential use of urine cell free DNA as a marker for cancer. (1st December 2016)

• Record Type: Journal Article
• Authors: Salvi, Samanta; Martignano, Filippo; Molinari, Chiara; Gurioli, Giorgia; Calistri, Daniele; De Giorgi, Ugo; Conteduca, Vincenza; Casadio, Valentina
• Is Part Of: Expert review of molecular diagnostics. Volume 16:Number 12(2016)
• Page Start: 1283
• Page End: 1290
• Publication Date: 2016-12-01
• Subjects: Urine -- cell free DNA -- cancer -- liquid biopsy -- markers; Molecular diagnosis -- Periodicals; 616.0758205
• DOI: 10.1080/14737159.2016.1254551
• Languages: English
• ISSNs: 1473-7159

Abstract

ABSTRACT: Introduction : Although the role of circulating cell free DNA in cancer has been widely demonstrated, less is known about the role of urine cell free DNA (UcfDNA). UcfDNA can serve as a 'liquid biopsy' for urological and non-urological tumors, as it carries information on DNA from cells exfoliated in urine and from circulation. Areas covered : We review the studies on UcfDNA as a source of biomarkers for cancer, focusing on the new techniques and the differences between urological and non-urological tumors. We searched Pubmed for articles published between 1998 and 2016 with the following key words and phrases: 'urine' and 'cell free DNA' or 'liquid biopsy' or 'cancer'. Expert commentary : Despite the few papers published on this topic, UcfDNA is an important component of 'liquid biopsy', a useful and non-invasive tool for cancer diagnosis, prognosis and treatment monitoring, containing a wide range of genetic information.