Decreased percentage of NKG2D+NK cells in patients with incident onset of Type 1 Diabetes. (February 2017)

• Record Type: Journal Article
• Authors: Zhang, Yupan; Wang, Haifeng; Lou, Xiaoqian; Qu, Xiaozhang; Gao, Lichao; Liu, Xiaolei; Li, Man; Guo, Hui; Jiang, Yanfang
• Is Part Of: Clinical and experimental pharmacology and physiology. Volume 44:Number 2(2017:Feb.)
• Page Start: 180
• Page End: 190
• Publication Date: 2017-02
• Subjects: KIR2DL3 -- natural killer cells -- NKG2A -- NKG2D -- type 1 diabetes mellitus; Clinical pharmacology -- Periodicals; Pharmacology, Experimental -- Periodicals; Physiology, Experimental -- Periodicals; Physiology, Pathological -- Periodicals; 615.1
• DOI: 10.1111/1440-1681.12699
• Languages: English
• ISSNs: 0305-1870

Abstract

Summary: Type 1 diabetes mellitus (T1DM) is characterized by absolute insulin deficiency owing to autoimmune destruction of the pancreatic β cells. A significant decrease in natural killer (NK) cells in peripheral blood has been observed in patients with untreated T1DM. In the present study, we aimed to explore the role of NK cells and their subsets in young T1DM patients. A total of 30 children and adolescents with untreated T1DM and 27 healthy controls (HC) were recruited in this study. Flow cytometry analysis indicated that the percentage of peripheral blood CD3‐CD56+ NK cells and NK cells subsets (CD56bright, CD56dim and CD56neg), were significantly decreased in the T1DM patients compared to healthy controls. In addition, the percentage of inducible CD107a+ and IFN‐γ‐secreting NK cells was significantly decreased compared to HC. Interestingly, the percentage of NKG2D+ NK cells negatively correlated with the level of serum TCHOL and TG in T1DM patients. Our data indicate that decreased number and impaired function of NK cells may have a role in the pathogenesis of T1DM.