The potential role of tissue‐engineered urethral substitution: clinical and preclinical studies. (3rd December 2015)

• Record Type: Journal Article
• Authors: Atala, Anthony; Danilevskiy, Mikhail; Lyundup, Alexey; Glybochko, Petr; Butnaru, Denis; Vinarov, Andrey; Yoo, James J.
• Is Part Of: Journal of tissue engineering and regenerative medicine. Volume 11:Number 1(2017)
• Page Start: 3
• Page End: 19
• Publication Date: 2015-12-03
• Subjects: urethral strictures -- urethroplasty -- regenerative medicine -- tissue engineering -- tissue‐engineered constructs -- matrices -- scaffolds; Tissue engineering -- Periodicals; Regeneration (Biology) -- Periodicals; 610.28
• DOI: 10.1002/term.2112
• Languages: English
• ISSNs: 1932-6254

Abstract

Abstract: Urethral strictures and anomalies remain among the difficult problems in urology, with urethroplasty procedures being the most effective treatment options. The two major types of urethroplasty are anastomotic urethroplasty and widening the urethral lumen using flaps or grafts (i.e. substitution urethroplasty). However, no ideal material for the latter has been found so far. Designing and selecting such a material is a necessary and challenging endeavour, driving the need for further bioengineered urethral tissue research. This article reviews currently available studies on the potentialities of tissue engineering in urethral reconstruction, in particular those describing the use of both acellular and recellularized tissue‐engineered constructs in animal and human models. Possible future developments in this field are also discussed. Copyright © 2015 John Wiley & Sons, Ltd.