Design of Hydrated Porphyrin‐Phospholipid Bilayers with Enhanced Magnetic Resonance Contrast. Issue 1 (14th October 2016)

• Record Type: Journal Article
• Authors: Shao, Shuai; Do, Trang Nhu; Razi, Aida; Chitgupi, Upendra; Geng, Jumin; Alsop, Richard J.; Dzikovski, Boris G.; Rheinstädter, Maikel C.; Ortega, Joaquin; Karttunen, Mikko; Spernyak, Joseph A.; Lovell, Jonathan F.
• Is Part Of: Small. Volume 13:Issue 1(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-10-14
• Subjects: bilayers -- contrast agents -- MD simulations -- porphyrin‐phospholipid -- water permeation; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201602505
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Computer simulations are used to design more hydrated bilayers, formed from amine‐modified porphyrin‐phospholipids (PoPs). Experiments confirm that the new constructs give rise to bilayers with greater water content. When chelated with manganese, amine‐modified PoPs provide improved contrast for magnetic resonance and are safely used for imaging in vivo.