The resistance and transmission mechanism of Acinetobacter baumannii isolates in a tertiary care hospital, China. (1st November 2016)

• Record Type: Journal Article
• Authors: Sun, Fengjun; Ou, Qianyi; Wang, Qian; Feng, Wei; Qiu, Xuewen; Chen, Jianhong; Liu, Yao; Xia, Peiyuan
• Is Part Of: Journal of chemotherapy. Volume 28:Number 6(2016:Dec.)
• Page Start: 476
• Page End: 481
• Publication Date: 2016-11-01
• Subjects: Acinetobacter baumannii -- Pulsed-field gel electrophoresis -- Resistance -- Transmission mechanism; Chemotherapy -- Periodicals; Drug Therapy -- Periodicals; 615.58
• DOI: 10.1080/1120009X.2016.1139335
• Languages: English
• ISSNs: 1120-009X

Abstract

Abstract : The aim of this study was to analyse the resistance and epidemiological data of 117 Acinetobacter baumannii isolates from Southwest Hospital, Chongqing, China. Except for polymyxin B, tigecycline, minocycline, cefoperazone/sulbactam, amikacin and levofloxacin, the resistance rates of other antimicrobial agents were above 90%. All the clinical isolates had the bla OXA-51 gene and 114 isolates had the bla OXA-23 gene. Forty-nine isolates were found to contain the bla IMP-4 gene. PFGE data showed that 117 isolates were divided into 25 groups. Sixty-three (53.85%) were found to carry the class 1 integron, and the sequence analysis of the class 1 integron internal variable regions – five types, one of which had the bla IMP-4 gene. For the bla IMP-4 positive strain without class 1 integron, we found the flanking sequence had the TnpA gene. The result suggested that the resistance gene was widely distributed in our hospital; moreover, the modes of presence and transmission are different and complicated. The results of our study can improve the infection empirical treatment method and infection control programme.