Benefits of temporary portocaval shunt during orthotopic liver transplantation with vena cava preservation: A propensity score analysis. Issue 2 (30th December 2016)

• Record Type: Journal Article
• Authors: Rayar, Michel; Levi Sandri, Giovanni B.; Cusumano, Caterina; Locher, Clara; Houssel‐Debry, Pauline; Camus, Christophe; Lombard, Nicolas; Desfourneaux, Veronique; Lakehal, Mohamed; Meunier, Bernard; Sulpice, Laurent; Boudjema, Karim
• Is Part Of: Liver transplantation. Volume 23:Issue 2(2017:Feb.)
• Page Start: 174
• Page End: 183
• Publication Date: 2016-12-30
• Subjects: Liver -- Transplantation -- Periodicals; Liver -- Diseases -- Periodicals; Liver Transplantation -- Periodicals; Foie -- Greffe -- Périodiques; 617.5560592
• DOI: 10.1002/lt.24650
• Languages: English
• ISSNs: 1527-6465

Abstract

Abstract : During orthotopic liver transplantation (OLT), clamping of the portal vein induces splanchnic venous congestion and accumulation of noxious compounds. These adverse effects could increase ischemia/reperfusion injury and subsequently the risk of graft dysfunction, especially for grafts harvested from extended criteria donors (ECDs). Temporary portocaval shunt (TPCS) could prevent these complications. Between 2002 and 2013, all OLTs performed in our center were retrospectively analyzed and a propensity score matching analysis was used to compare the effect of TPCS in 686 patients (343 in each group). Patients in the TPCS group required fewer intraoperative transfusions (median number of packed red blood cells—5 versus 6; P = 0.02; median number of fresh frozen plasma—5 versus 6; P = 0.02); had improvement of postoperative biological parameters (prothrombin time, Factor V, international normalized ratio, alkaline phosphatase, and gamma‐glutamyltransferase levels); and showed significant reduction of biliary complications (4.7% versus 10.2%; P = 0.006). Survival analysis revealed that TPCS improved 3‐month graft survival (94.2% versus 88.6%; P = 0.01) as well as longterm survival of elderly (ie, age > 70 years) donor grafts ( P = 0.02). In conclusion, the use of TPCS should be recommended especially when considering an ECD graft. Liver Transplantation 23 174–183 2017 AASLD