Role of 18F‐FDG PET/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma. (2nd August 2016)

• Record Type: Journal Article
• Authors: Elkhatib, Ahmad H.; Soldatova, Liuba; Carrau, Ricardo L.; Hachem, Ralph Abi; Ditzel, Leo; Campbell, Raewyn; Prevedello, Daniel M.; Prevedello, Luciano; Filho, Leo F. S. Ditzel; Campbell, Raewyn G.
• Is Part Of: Laryngoscope. Volume 127:Number 2(2017)
• Page Start: 321
• Page End: 324
• Publication Date: 2016-08-02
• Subjects: olfactory neuroblastoma -- SNUC -- sinonasal undifferentiated carcinoma -- PET/CT -- SUVmax; Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.26194
• Languages: English
• ISSNs: 0023-852X

Abstract

Abstract : Objectives: The purpose of this study is to demonstrate the potential contribution of positron emission tomography (PET)/computed tomography (CT) to help differentiate olfactory neuroblastoma (ONB) from sinonasal undifferentiated carcinoma (SNUC). Methods: Following approval by the institutional review board at the Wexner Medical Center at the Ohio State University, Columbus, Ohio, a pilot study with retrospective review of patients with biopsy‐proven diagnosis of ONB s and SNUC s was conducted. Staging PET/CT scans were reviewed to document the maximum standardized uptake value (SUVmax). A statistical comparison of SUVmax was performed. Results: We identified 13 patients (7 with ONBs and 6 with SNUCs) with mean age 60.2 years who had undergone staging F‐18 fluorodeoxyglucose ( 18 F‐FDG) PET/CT of the primary tumor at the time of their diagnosis. Mean SUVmax was found to be five‐fold higher in SNUC patients (35.63, range 10.8–77.9) than in ONB patients (7.24, range 4.6–10.7) ( P ≤ 0.00169). Conclusion: Maximum standardized uptake value of 18 F‐FDG PET/CT can be used to initially discriminate between ONB and SNUC. This finding may prove helpful to guide diagnostic and treatment planning when the histopathologic diagnosis is inconclusive. Level of Evidence: 4. Laryngoscope, 2016 127:321–324, 2017