The Correlation Between the Serum Squamous Carcinoma Antigen and the Prognosis of Recurrent Cervical Squamous Carcinoma. Issue 1 (20th July 2016)

• Record Type: Journal Article
• Authors: Wang, Yan; Cui, Tong; Du, Lili; Xu, Xiaoqin; Tian, Baoguo; Sun, Ting; Han, Cunzhi; Zhao, Xianwen; Jing, Jiexian
• Is Part Of: Journal of clinical laboratory analysis. Volume 31:Issue 1(2017:Jan.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-07-20
• Subjects: cervical carcinoma -- prognosis -- squamous cell carcinoma antigen -- tumor recurrence; Diagnosis, Laboratory -- Periodicals; Medical laboratory technology -- Periodicals; 616
• DOI: 10.1002/jcla.22020
• Languages: English
• ISSNs: 0887-8013

Abstract

Abstract : Background: To explore the relationship of the serum squamous cell carcinoma antigen (SCC‐Ag) with the pathologic characteristics, occurrence, and prognosis of cervical squamous carcinoma. Methods: The enzyme‐linked immunosorbent assay (ELISA) method was used to determine the serum SCC‐Ag levels for the patients, which included 424 pretreatment patients and 500 cases after treatment. Results: (a) Pretreatment SCC‐Ag levels of patients were related to clinical stages, lymphatic metastasis, and myometrial invasion, (b) within a median follow‐up of 54 months, 180 recurrences (36%) and 102 disease‐associated deaths (20.4%) were recorded, 161 recurrent patients showed elevated SCC‐Ag levels (161/180, 89.4%), and 60 of them (37.3%) had a significant increase in SCC‐Ag serum levels before clinical manifestation of relapse. The lead time ranged between 1 and 5 months (median: 2.3 months). The total survival rates were 23.4% and 17.8% for 3‐year and 5‐year period, respectively, and (c) clinical stages, the site of recurrence, and SCC‐Ag levels after treatment were closely related with recurrent patients' survival time ( P < 0.01~<0.005). Multivariate analysis indicated that the clinical stages and SCC‐Ag levels of recurrent patients were independent prognostic factors ( P < 0.05˜0.01). Conclusion: Serum SCC‐Ag level was an important predictor for the cervical squamous carcinoma recurrence and prognosis.