Cancer stem cells: A product of clonal evolution?. Issue 5 (12th October 2016)
- Record Type:
- Journal Article
- Title:
- Cancer stem cells: A product of clonal evolution?. Issue 5 (12th October 2016)
- Main Title:
- Cancer stem cells: A product of clonal evolution?
- Authors:
- van Niekerk, Gustav
Davids, Lester M.
Hattingh, Suzèl M.
Engelbrecht, Anna‐Mart - Abstract:
- Abstract : The cancer stem cell (CSC) model has emerged as a prominent paradigm for explaining tumour heterogeneity. CSCs in tumour recurrence and drug resistance have also been implicated in a number of studies. In fact, CSCs are often identified by their expression of drug‐efflux proteins which are also highly expressed in normal stem cells. Similarly, pro‐survival or proliferation signalling often exhibited by stem cells is regularly reported as being upregulated by CSC. Here we review evidence suggesting that many aspects of CSCs are more readily described by clonal evolution. As an example, cancer cells often exhibit copy number gains of genes involved in drug‐efflux proteins and pro‐survival signalling. Consequently, clonal selection for stem cell traits may result in cancer cells developing "stemness" traits which impart a fitness advantage, without strictly following a CSC model. Finally, since symmetric cell division would give rise to more cells than asymmetric division, it is expected that more advanced tumours would depart from a CSC. Collectively, these observations suggest clonal evolution may explain many aspects of the CSC.
- Is Part Of:
- International journal of cancer. Volume 140:Issue 5(2017:Mar. 01)
- Journal:
- International journal of cancer
- Issue:
- Volume 140:Issue 5(2017:Mar. 01)
- Issue Display:
- Volume 140, Issue 5 (2017)
- Year:
- 2017
- Volume:
- 140
- Issue:
- 5
- Issue Sort Value:
- 2017-0140-0005-0000
- Page Start:
- 993
- Page End:
- 999
- Publication Date:
- 2016-10-12
- Subjects:
- aldehyde dehydrogenase -- ATP‐binding cassette -- cancer stem cells -- clonal evolution -- drug resistance -- micro‐environment
Cancer -- Periodicals
Cancer -- Prevention -- Periodicals
616.994 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0215 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/ijc.30448 ↗
- Languages:
- English
- ISSNs:
- 0020-7136
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4542.156000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 1563.xml