Choroidal and macular thickness changes in type 1 diabetes mellitus patients without diabetic retinopathy. Issue 8 (16th November 2016)

• Record Type: Journal Article
• Authors: Yolcu, Umit; Çağıltay, Eylem; Toyran, Sami; Akay, Fahrettin; Uzun, Salih; Gundogan, Fatih C.
• Is Part Of: Postgraduate medicine. Volume 128:Issue 8(2016)
• Page Start: 755
• Page End: 760
• Publication Date: 2016-11-16
• Subjects: Choroidal thickness -- diabetes mellitus -- optical coherence tomography -- retinal thickness; Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610.5
• DOI: 10.1080/00325481.2016.1210475
• Languages: English
• ISSNs: 0032-5481

Abstract

ABSTRACT: Objectives : To explore choroidal thickness (ChT) and retinal thickness (RT) changes in patients with type 1 diabetes mellitus (DM). Methods : Sixty patients with Type 1 DM and 60 age- and sex-matched healthy controls were included in this prospective case–control clinical study. All patients underwent a complete ophthalmological examination. ChT of each participant was measured at the fovea and horizontal nasal and temporal quadrants at 500-µm intervals to 1500 µm from the foveola using spectral-domain optical coherence tomography (SD-OCT). Age, gender, disease duration, serum glycosylated hemoglobin (HbA1c), fasting glucose level, axial length (AL) and refractive error were noted and analyzed. Results : Mean disease duration, mean HbA1c and mean fasting blood glucose in diabetic patients were 6.1±2.8 years, (8.9±0.9)% and 287.5±69.1 mg/dl, respectively. Age, gender, AL, spherical equivalent differences between the patients and subjects were insignificant (p>0.05). Subfoveal ChT, nasal quadrant ChT measurements, temporal 1500 µm and mean nasal ChT were significantly lower in diabetic patients (p<0.05 for all). Temporal 500 µm and 1000 µm ChT measurements, mean temporal ChT, average ChT, central macular thickness and average macular thickness did not differ significantly between the groups (p>0.05 for all). Conclusion : This study showed that there is choroidal thinning in young Type 1 diabetic patients with early period of disease duration without diabetic retinopathy nor any other systemic diseases. Choroidal changes in type 1 DM seem to begin at nasal and distal temporal retina. These results need to be verified by larger and longitudinal studies.