Identification of the mechanical parameters for the human uterus in vivo using intrauterine pressure measurements. (8th April 2016)

• Record Type: Journal Article
• Authors: Sharifimajd, Babak; Ölvander, Johan; Stålhand, Jonas
• Is Part Of: International journal for numerical methods in biomedical engineering. Volume 33:Number 1(2017:Jan.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-04-08
• Subjects: human uterine smooth muscle mechanics -- intrauterine pressure -- parameter identification -- response surface methodology; Biomedical engineering -- Periodicals; Imaging systems in medicine -- Periodicals; Numerical analysis -- Periodicals; Engineering mathematics -- Periodicals; 610.28
• DOI: 10.1002/cnm.2778
• Languages: English
• ISSNs: 2040-7939

Abstract

Summary: There are limited experimental data to characterize the mechanical response of human myometrium. A method is presented in this work to identify mechanical parameters describing the active response of human myometrium from the in vivo intrauterine pressure measurements. The human uterine contraction during labor is simulated by implementing a coupled model in a finite element scheme, and the intrauterine pressure is evaluated as the outcome. A meta‐model is developed to approximate the finite element simulation response with a lower computational cost and used to identify model parameters through fitting its prediction to the in vivo measurements. Copyright © 2016 John Wiley & Sons, Ltd. Abstract : This study addresses a method to identify mechanical parameters that describe the active response of uterine smooth muscle from in vivo intrauterine pressure measurements. A model is developed and implemented in a finite element program to compute the intrauterine pressure during labor. By fitting the response of this model to the clinical measurements, the desired parameters are identified.