A semi‐adaptive control approach to closed‐loop medication infusion. (30th May 2016)

• Record Type: Journal Article
• Authors: Jin, Xin; Kim, Chang‐Sei; Dumont, Guy A.; Ansermino, J. Mark; Hahn, Jin‐Oh
• Is Part Of: International journal of adaptive control and signal processing. Volume 31:Number 2(2017)
• Page Start: 240
• Page End: 254
• Publication Date: 2016-05-30
• Subjects: semi‐adaptive control -- medication infusion -- direct dynamic dose‐response model -- model‐reference adaptive control -- composite adaptive control; Adaptive control systems -- Periodicals; Adaptive signal processing -- Periodicals; 629.836
• DOI: 10.1002/acs.2696
• Languages: English
• ISSNs: 0890-6327

Abstract

Summary: This paper presents a semi‐adaptive control approach to closed‐loop medication infusion problems. The rationale underlying this approach is to design a controller that can adapt model parameters with a large impact on the model's fidelity while fixing the remaining parameters at nominal values. In this paper, a control‐oriented model for this purpose is derived via system identification and sensitivity analysis of a low‐order model capturing the direct dose‐response relationship Using the model thus derived, a model‐reference adaptive controller and a composite adaptive controller are designed and compared with each other. In‐silico simulation results using remifentanil's effect on respiratory rate as an example indicate that both controllers can regulate the output at commanded set points. Copyright © 2016 John Wiley & Sons, Ltd.