A Copper‐Benzotriazole‐Based Coordination Polymer Catalyzes the Efficient One‐Pot Synthesis of (N′‐Substituted)‐hydrazo‐4‐aryl‐1, 4‐dihydropyridines from Azines. Issue 1 (21st December 2016)

• Record Type: Journal Article
• Authors: Kallitsakis, Michael; Loukopoulos, Edward; Abdul‐Sada, Alaa; Tizzard, Graham J.; Coles, Simon J.; Kostakis, George E.; Lykakis, Ioannis N.
• Is Part Of: Advanced synthesis & catalysis. Volume 359:Issue 1(2017)
• Page Start: 138
• Page End: 145
• Publication Date: 2016-12-21
• Subjects: 1, 4-dihydropyridines -- azines -- catalysis -- coordination polymers -- copper; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201601072
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A series of new ( N′ ‐substituted)‐hydrazo‐4‐aryl‐1, 4‐dihydropyridines was successfully synthesized via a facile one‐pot catalytic pathway utilizing azines and propiolate esters as starting materials and a one‐dimensional copper benzotriazole‐based coordination polymer as catalyst. In the absence of catalyst, the corresponding 5‐substituted 4, 5‐dihydropyrazoles were formed in moderate to high yields. Fine‐tuning of the catalysts allowed us to gain more insights regarding the plausible reaction mechanism. Abstract :