Development and evaluation of targeting ligand-anchored CNTs as prospective targeted drug delivery system. (17th February 2017)

• Record Type: Journal Article
• Authors: Kaur, Sumandeep; Mehra, Neelesh Kumar; Jain, Keerti; Jain, Narendra Kumar
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 45:Number 2(2017)
• Page Start: 242
• Page End: 250
• Publication Date: 2017-02-17
• Subjects: 5-Fluorouracil -- carbon nanotubes -- folic acid -- ligands -- PEGylation -- targeting -- tumor; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.3109/21691401.2016.1146728
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: Our main investigation in the present research was to developt and evaluate targeting ligand-anchored multiwalled carbon nanotubes (MWCNTs) as prospective targeted drug delivery system, with a special focus on the MWCNTs surface functionalization (FA-PEG bis-amine functionalized, carboxylated MWCNTs). In vitro release of 5-fluorouracil (5-FU) was studied at pH 7.4 phosphate buffer and 5.5 acetate buffer, which displayed initial faster followed by sustained release up to 900 min. Further, 5-FU/FA-PEG bis amine-MWCNTs was found to be long circulating, prolonged half-life and increased drug accumulation in target tissue.