Bioactive PLGA–curcumin microparticle-embedded chitosan scaffold: in vitro and in vivo evaluation. (17th February 2017)

• Record Type: Journal Article
• Authors: Amirthalingam, Muthukumar; Kasinathan, Narayanan; Amuthan, Arul; Mutalik, Srinivas; Sreenivasa Reddy, M.; Nayanabhirama, Udupa
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 45:Number 2(2017)
• Page Start: 233
• Page End: 241
• Publication Date: 2017-02-17
• Subjects: Chitosan scaffold -- curcumin microparticles -- design of experiments -- tissue regeneration -- wound healing; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.3109/21691401.2016.1146727
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: Wound healing is a complex process affected by several factors. In the present work, novel biocompatible PLGA–curcumin microparticle-embedded chitosan scaffold was fabricated for wound-healing application. Process variables involved in the preparation of microparticles were optimized using design of experiment. Scanning electron microscopy (SEM) confirmed the porous nature of scaffold with embedded microparticles. A maximum release of 14% of the encapsulated curcumin was observed at 12th hour. Modified tube dilution method showed that scaffold significantly ( p < 0.05) reduced multiplication of Staphylococcus aureus. More than 50% of the excised wound in rats healed in 4 days with an epithilization period of 18 days.