Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women. (December 2016)

• Record Type: Journal Article
• Authors: Figueroa, Arturo; Alvarez‐Alvarado, Stacey; Jaime, Salvador J; Johnson, Sarah A; Campbell, Jeremiah C; Feresin, Rafaela G; Elam, Marcus L; Navaei, Negin; Pourafshar, Shirin; Arjmandi, Bahram H
• Is Part Of: Clinical and experimental pharmacology and physiology. Volume 43:Number 12(2016:Dec.)
• Page Start: 1243
• Page End: 1246
• Publication Date: 2016-12
• Subjects: aging -- aortic haemodynamic responses -- appendicular skeletal muscle mass -- arterial stiffness -- isometric exercise -- obesity; Clinical pharmacology -- Periodicals; Pharmacology, Experimental -- Periodicals; Physiology, Experimental -- Periodicals; Physiology, Pathological -- Periodicals; 615.1
• DOI: 10.1111/1440-1681.12655
• Languages: English
• ISSNs: 0305-1870

Abstract

Summary: Sarcopenia, defined by reduced appendicular skeletal muscle mass (ASM)/height 2 (ASMI), is associated with increased arterial stiffness (brachial‐ankle pulse wave velocity, baPWV) and wave reflection (augmentation index, AIx). Blood pressure (BP) responses to metaboreflex activation (post‐exercise muscle ischemia, PEMI) are exaggerated in older prehypertensives and hypertensives. We examined peripheral and aortic haemodynamics at rest and during PEMI in postmenopausal women with low‐ASMI and normal‐ASMI. Resting radial AIx and baPWV as well as brachial and aortic systolic BP, pulse pressure, systolic time index, and subendocardial viability ratio (SEVR) responses to PEMI were greater in women with low‐ASMI than normal‐ASMI. Increased baPWV associated with low‐ASMI may play a major role in the exaggerated pulse pressure and SEVR responses to PEMI in postmenopausal women.