Atypical teratoid/rhabdoid tumor arising in a malignant glioma. Issue 1 (29th July 2016)

• Record Type: Journal Article
• Authors: Bozzai, Barbara; Hasselblatt, Martin; Turányi, Eszter; Frühwald, Michael C.; Siebert, Reiner; Bens, Susanne; Schneppenheim, Reinhard; Kool, Marcel; Stelczer, Gábor; Hortobágyi, Tibor; Hauser, Peter
• Is Part Of: Pediatric blood & cancer. Volume 64:Issue 1(2017)
• Page Start: 96
• Page End: 99
• Publication Date: 2016-07-29
• Subjects: atypical teratoid/rhabdoid tumor -- glioblastoma -- irradiation -- pleomorphic xanthoastrocytoma -- temozolomide -- therapy‐induced secondary tumor; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26173
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irradiation, and bevacizumab. AT/RT was diagnosed as a secondary tumor, 2.5 years following primary diagnosis. The child died 13 months after the diagnosis of AT/RT. This case demonstrates that malignant gliomas may give rise to AT/RT. It also emphasizes the diagnostic value of a repeated tumor biopsy in the recurrence setting.