Aster yomena suppresses LPS-induced cyclooxygenase-2 and inducible nitric oxide synthase expression. Issue 2 (4th March 2017)

• Record Type: Journal Article
• Authors: Kim, Ji-Soo; Kim, Ah-Yeon; Shin, Hyeon-Myeong; Ahn, Sang-Il; Shim, Hyun-Jin; Nam, Kung-Woo; Hwang, Kyung-A; Youn, Hyung-Sun
• Is Part Of: Food and agricultural immunology. Volume 28:Issue 2(2017)
• Page Start: 202
• Page End: 210
• Publication Date: 2017-03-04
• Subjects: Aster yomena -- inflammation -- nuclear factor-κB -- cyclooxygenase-2 -- inducible nitric oxide synthase; Immunochemistry -- Periodicals; Food -- Analysis -- Periodicals; Immunoassay -- Periodicals; 616.079
• DOI: 10.1080/09540105.2016.1251395
• Languages: English
• ISSNs: 0954-0105

Abstract

ABSTRACT: Inflammation is a pathological process that is known to be involved in numerous diseases. Microbial infection or tissue injury activates inflammatory responses, resulting in the induction of proinflammatory proteins including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Aster yomena is used in traditional Korean remedies to treat cough, asthma, and insect bites. Here, we investigated the effects of A. yomena extract (EAY) on the expression of COX-2 and iNOS induced by LPS. EAY inhibited NF-κB activation and IκBα degradation induced by LPS. EAY suppressed LPS-induced COX-2 and iNOS expression which are the target genes regulated through NF-κB activation in macrophages. EAY also suppressed LPS-induced nitrite production. These results suggest that EAY has the potential to be developed as a potent anti-inflammatory drug.