The roles of extracellular related-kinases 1 and 2 signaling in CNS myelination. (November 2016)

• Record Type: Journal Article
• Authors: Gonsalvez, David; Ferner, Anita H.; Peckham, Haley; Murray, Simon S.; Xiao, Junhua
• Is Part Of: Neuropharmacology. Volume 110:Part B(2016)
• Page Start: 586
• Page End: 593
• Publication Date: 2016-11
• Subjects: Erk -- Akt -- Fyn -- BDNF -- Oligodendrocyte -- Myelin; Erk1/2 extracellular related-kinase 1 and 2 -- BDNF brain-derived neurotrophic factor -- NGF nerve growth factor -- NT-3 neurotrophin 3 -- CNS central nervous system -- PNS peripheral nervous system -- p75NTR p75 neurotrophin receptor -- TrkB tropomyosin-related kinase receptor B -- OPC oligodendrocyte precursor cell -- MBP myelin basic protein -- MOG myelin oligodendrocyte glycoprotein -- pTrkB phospho-TrkB -- pErk1/2 phospho-Erk1/2 -- MAPK mitogen-activated protein kinase -- MEK Mitogen/Extracellular signal-regulated Kinase -- NRG Neuregulin 1 -- mTOR mammalian target of rapamycin -- IRS-1 insulin receptor substrate-1 -- GSK3 glycogen synthase kinase-3; Neuropsychopharmacology -- Periodicals; Autonomic Agents -- Periodicals; Neuropsychopharmacologie -- Périodiques; Neuropsychopharmacology; Periodicals; Electronic journals; 615.78
• DOI: 10.1016/j.neuropharm.2015.04.024
• Languages: English
• ISSNs: 0028-3908

Abstract

Abstract: Substantial progress has been made in identifying the intracellular signaling pathways that regulate central nervous system myelination. Recently, the mitogen activated protein kinase pathway, in particular the extracellular signal-related kinase 1 (Erk1) and Erk2, have been identified as critically important in mediating the effects of several growth factors that regulate oligodendroglial development and myelination. Here we will review the recent studies that identify the key role that Erk1/2 signaling plays in regulating oligodendroglial development, myelination and remyelination, discuss the potential mechanisms that Erk1/2 may utilize to influence myelination, and highlight some questions for further research. This article is part of the Special Issue entitled 'Oligodendrocytes in Health and Disease'. Highlights: Erk1/2 signalling regulates oligodendroglial survival, proliferation and differentiation. Erk1/2 signalling regulates CNS myelination and remyelination. Erk1/2 signalling cross talk with other pathways involved in CNS myelination. Erk1/2 are potential activators of myelin-specific transcription factors.