Shared mechanisms in physiological and pathological nucleoplasmic reticulum formation. (2nd January 2017)

• Record Type: Journal Article
• Authors: Drozdz, Marek Mateusz; Vaux, David John
• Is Part Of: Nucleus. Volume 8:Number 1(2017)
• Page Start: 34
• Page End: 45
• Publication Date: 2017-01-02
• Subjects: cytoskeleton -- chromosome territories -- gene expression -- membrane curvature -- nucleoplasmic reticulum -- NR -- nuclear envelope -- NE; Cell nuclei -- Periodicals; Biology -- Periodicals; Biology; Cell nuclei; Periodicals; 571.6605
• DOI: 10.1080/19491034.2016.1252893
• Languages: English
• ISSNs: 1949-1034

Abstract

ABSTRACT: The mammalian nuclear envelope (NE) can develop complex dynamic membrane-bounded invaginations in response to both physiological and pathological stimuli. Since the formation of these nucleoplasmic reticulum (NR) structures can occur during interphase, without mitotic NE breakdown and reassembly, some other mechanism must drive their development. Here we consider models for deformation of the interphase NE, together with the evidence for their potential roles in NR formation.