Neodymium-doped NaHoF4 nanoparticles as near-infrared luminescent/T2-weighted MR dual-modal imaging agents in vivo. Issue 3 (15th December 2016)

• Record Type: Journal Article
• Authors: Feng, Yamin; Xiao, Qingbo; Zhang, Yanhui; Li, Fujin; Li, Yanfang; Li, Chunyan; Wang, Qiangbin; Shi, Liyi; Lin, Hongzhen
• Is Part Of: Journal of materials chemistry. Volume 5:Issue 3(2017)
• Page Start: 504
• Page End: 510
• Publication Date: 2016-12-15
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c6tb01961g
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Efficient NIR luminescence and high r 2 value are simultaneously achieved for NaHoF4 :Nd 3+ nanoplates, which are successfully applied for NIR luminescence and MR imaging in vivo . Abstract : The achievement of efficient near-infrared (NIR) luminescence of lanthanide ions in a paramagnetic nanoparticle (NP) host is highly desirable to optimize the performance of multimodal bioprobes. Herein, we present a facile coprecipitation method to prepare highly uniform NaHoF4 :Nd 3+ nanoplates. Upon NIR excitation at 785 nm, efficient NIR luminescence of Nd 3+ can be obtained from the paramagnetic NaHoF4 hosts. More interestingly, due to energy transfer from the excited state of Nd 3+ to the adjacent Ho 3+, NIR emission at around 1200 nm from Ho 3+ ions is also observed. The r 2 value of NaHoF4 :Nd 3+ NPs reaches 143.7 s −1 mM −1 at a high magnetic field of 11.7 T. By modifying with hydrophilic alpha-cyclodextrin, the NaHoF4 :Nd 3+ NPs were further successfully applied for the NIR luminescent/ T 2 -weighted MR dual-modal in vivo imaging of nude mice, high contrast NIR imaging of the liver and T 2 -weighted MR imaging of stem cells in the mouse brain using the NaHoF4 :Nd 3+ NPs as multimodal bioprobes.