Piperidine promoted aldol reaction of alkynyl aldehydes and ethyl diazoacetate. Issue 7 (15th February 2017)

• Record Type: Journal Article
• Authors: Zhang, Guifu; Sun, Sheng; Jiang, Longqiang; Sun, Shaofa; Luo, Xing; Chen, Zhi; Guo, Haibing; Xing, Yalan
• Is Part Of: Tetrahedron letters. Volume 58:Issue 7(2017)
• Page Start: 649
• Page End: 651
• Publication Date: 2017-02-15
• Subjects: Aldol reaction -- Piperidine -- Diazoacetate -- Alkynyl aldehyde; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.01.001
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Efficient synthesis of complex diazo compounds containing propargyl alcohol. Aldol reaction of alkynyl aldehydes and ethyl diazoacetate. Easy operation, ambient temperature, good yields. Broad functional group tolerance. Abstract: Complex diazo compounds containing propargyl alcohol functional group were prepared by an efficient aldol reaction of alkynyl aldehydes and ethyl diazoacetate in good yields. Piperidine was utilized as a base to catalyze this transformation. The aldol reaction showed broad substrate scopes and good functional group compatibility.