Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes. (February 2017)

• Record Type: Journal Article
• Authors: Giongo, Janice L.; Vaucher, Rodrigo A.; Da Silva, Aleksandro S.; Oliveira, Camila B.; de Mattos, Cristiane B.; Baldissera, Matheus D.; Sagrillo, Michele R.; Monteiro, Silvia G.; Custódio, Dayana L.; Souza de Matos, Marcielly; Sampaio, Paulo T.; Teixeira, Helder F.; Koester, Letícia S.; da Veiga Junior, Valdir F.
• Is Part Of: Microbial pathogenesis. Volume 103(2017)
• Page Start: 13
• Page End: 18
• Publication Date: 2017-02
• Subjects: Aniba canelilla -- Essential oil composition -- Antiprotozoal activity -- 1-Nitro-2-phenylethane -- Methyleugenol; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2016.12.006
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: Aniba canelilla (H.B.K.) Mez, popularly known as " casca-preciosa " (precious bark), is a plant of the Lauraceae family, widely distributed in the Amazon region. Its major constituent is 1-nitro-2-phenylethane, a rare molecule in plants which is responsible for this plant's cinnamon scent. The present study aimed to report the chemical characterization of the oil extracted from Aniba canelilla using gas-chromatography/mass spectrometry and to assess its in vitro trypanocidal activity against Trypanosoma evansi, a prevalent haemoflagellate parasite that affects a broad range of mammal species in Africa, Asia and South America. The oil presented 1-nitro-2-phenylethane (83.68%) and methyleugenol (14.83%) as the two major components. The essential oil as well as both major compounds were shown to exert trypanocidal effect. Methyleugenol was slightly more active than 1-nitro-2-phenylethane. In vitro studies showed that the oil extracted from the stems of A. canelilla may be regarded as a potential natural treatment for trypanosomosis, once proven their in vivo action, may be an interesting alternative in the treatment of infected animals with T. evansi. Graphical abstract: Highlights: Aniba canelilla essential oil has in vitro trypanocidal action against Trypanosoma evansi . Methyleugenol and 1-nitro-2-phenylethane, isolated or associated, has in vitro trypanocidal action. These compounds may be considered responsible for the in vitro trypanocidal action. A. canelilla may be considered an important approach to treat infected animals by T. evansi .