Dipstick proteinuria is a prognostic indicator of short-term mortality in patients with heart failure. (1st March 2017)

• Record Type: Journal Article
• Authors: Chen, Yuanhan; Cai, Lu; Du, Zhiming; Xu, Jiaqi; Tan, Ning; Ye, Zhiming; Liu, Shuangxin; Dong, Wei; Shi, Wei; Liang, Xinling
• Is Part Of: International journal of cardiology. Volume 230(2017)
• Page Start: 59
• Page End: 63
• Publication Date: 2017-03-01
• Subjects: AHF Acute heart failure -- CKD chronic kidney disease -- eGFR estimated glomerular filtration rate -- RRT renal replacement therapy -- ECG electrocardiogram -- NT-proBNP N-terminal pro-brain natriuretic peptide -- CRP C-reactive protein -- EFFECT Enhanced Feedback for Effective Cardiac Treatment; proteinuria -- acute heart failure -- prognostic indicator -- marker -- mortality; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2016.12.096
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: Proteinuria is common in patients with acute heart failure (AHF). This study investigated the relationship between proteinuria and short-term mortality among patients hospitalized for AHF at two university hospitals. Methods: Adult hospitalized patients with AHF were retrospectively studied. Proteinuria was defined based on the first urine dipstick test within 48 h after the AHF diagnosis. The death risk was assessed using an Enhanced Feedback for Effective Cardiac Treatment (EFFECT) 30-day mortality risk score. Results: Of the 1, 058 eligible patients with AHF, 583 (55.1%) exhibited proteinuria. The degree of proteinuria was positively correlated with poor AHF prognostic indicators (C-reactive protein and N-terminal pro-brain natriuretic peptide) and negatively correlated with protective indicators (basal estimated glomerular filtration rate, haemoglobin, and serum albumin). The EFFECT mortality risk score and the in-hospital mortality rate of patients with proteinuria were significantly higher than that of the patients without proteinuria. According to different multivariate logistic regression models, proteinuria increased the risk of in-hospital mortality after correcting for multiple variables, including the EFFECT mortality risk score, diabetes, RASI, NT-proBNP, albumin and chronic kidney disease stages. Compared with the NT-proBNP, proteinuria and degree of proteinuria yielded higher areas under the ROC curve for predicting in-hospital mortality. Conclusions: Our results demonstrate that proteinuria correlates with the short-term mortality rate of patients hospitalized for AHF. Dipstick proteinuria testing might represent a promising prognostic indicator for these patients.